IVIG

[JACK]

Does anyone use IVIG in the management of neonatal sepsis?
If yes what is the indication af starting IVIG in these neonates?
What has been your experience with IVIG in sepsis cases?

[Khaque]

Whilst we have been using IVIG to treat neonatal sepsis since 1986 but you may consider us biased as we were one of the first to publish the benefits of adjuvant IVIG therapy in neonatal sepsis. Since then there have been a number of studies supporting the use of IVIG (particularly IgM-enriched IVIG) in neonatal sepsis. Cochrane analysis has also shown benefits though the number to treat was 11. The INIS trial has recently finished and its report is eagerly awaited. For dosage, indications please refer to publications on the subject.