experience with use of MgSo4 in PHN

[thabit]

dear colleagues....
any body have an experience using MgSo4 in treating newborns with pulmonary hypertension ?
thanks

[selvanr4]

hello,
we have used mgso4 in treating PPHN in our newborns before sildenafil has been found to be useful. now we use it only when the response to sildenafil is inadequete.it is used initially as a bolus dose of 200mg /kg over 30 mts ,followed by 10mg/kg/hr (till you get a needed response in terms of reduced PIP,good sp02).beware of peripheral shock which might prompt us to discontinue the infusion.
dr.r.selvan
lotus hospital
ERODE,INDIA

[sameera_reddy]

MgSO4 has given way to Sidanefil .MgSO4 not only dilates pulmonary vessels but also causes peripheral vasodilatation.It will also causes relaxes the bronchial muscles therby causing increased ventilatory reqirements particularly PEEP. It also causes CNS depressin in these doses-Dr.Sameera