Phenobarbitone in neonatal cholestasis

[thabit]

Best wishes....
Any new experience with the use of phenobarbitone in treatment of neonatal cholestasis?
Thanks

[Stefan Johansson]

We do not administer phenobarbital in cases of neonatal cholestasis.
In PubMed I found these article in support of our strategy (but literature seems really sparse):
http://www.ncbi.nlm.nih.gov/pubmed/2324888
http://www.ncbi.nlm.nih.gov/pubmed/3517284

On the other hand, we may give ursodeoxycholic acid to infant (especially preterms) with cholestasis as a result of long-term TPN.
http://www.ncbi.nlm.nih.gov/pubmed/18223390

[takshafat]

we use phenobarb only in preparation for HIDA scan.we get a lot of cases where we have to differentiate between EHBA and severe cholestasis of other causes