Dosage of Erytromycinin Neonatal GERD

[sameera_reddy]

Hai,
During the care of preterms 29-32wks after the initaial days of Early NEC IS DONE WITH ,we encounter problems of feed residues(upto20-30-%).We initially start them on Domperidone0.1-0.2ml/kg/dose and if still present add up Omeprazole1mg/kg/day and if still persistent add up Erythromycin.There are conflicting dosage schedules here though we start at 10mg/kg/dose qid.I want to know from the forum whether such high dose will not result in gastritis though I have never encountered the same problem and also whether the dosing is correct:)

[ctestolin]

<32weeks: 10 mg/kg every 6 h for 2 daus then 4mg/kg every 6 h for 5 daus
> 32 weeks: 12,5 mg/kg every 6 h for 14 days

references
Ng .. Cochrane database syst rev 2008 jul 16;(3):CD001815
Aly ... J Perinatol 2007;27:39-43

[sameera_reddy]

Thank you for the input.