Preterm IUGR/SGA and elevated IRT

[kelly]

Good morning eveyone,
I am curious, Is anyone else seeing an increased number of IUGR/SGA premies with and increased IRT on newborn screening? Since starting my fellowship, I've notice that frequently our SGA babies are having abnormally evelated IRTs on newborn screen.

Have a great day
Kelly

[cihanber]

hi , what is IRT?

[kelly]

I'm sorry about using an abbreviation the might not be universal. IRT is immunoreactive trypsinogen

[Stefan Johansson]

I'm sorry about using an abbreviation the might not be universal. IRT is immunoreactive trypsinogen
Interesting observation!
Do you routinely check IRT in SGA infants?
(We don't)

[kelly]

Interesting observation!
Do you routinely check IRT in SGA infants?
(We don't)


Immunoreactive trypsinogen (IRT) is assessed on our newborn state screen, to screen for CF.

[drashishjain2000]

Have you looked for the causes for fault positive causes for the investigation

[Stefan Johansson]

Immunoreactive trypsinogen (IRT) is assessed on our newborn state screen, to screen for CF.

Could this finding be related to the blood flow re-distribution in utero of IUGR infants - that the reduced circulation in the abdominal organs somehow lead to elevated IRT? Have you checked Pubmed, your question may be a nice and well defined research idea?!

[mbayari]

hi all
IRT is a simple tool for population screening that has been used several years ago in France; if it returns positive,it should be confirmed by a sweat chloride testing and eventually by molecular biology. A lot of false positive results have been described but I'm notaware of any relation to IUGR/ SGA. Keep us knowing results of your searches please.